A novel method of nicotine quantification in electronic cigarette liquids and aerosols.

ABSTRACT: The electronic cigarette (e-cigarette) has emerged as popular electronic nicotine delivery devices (ENDs). However, the general safety and validity of e-cigarettes for nicotine delivery efficacy are still not well understood. This study developed a new method for efficient measurement of nicotine levels in both the liquids (e-liquids) used in e-cigarettes and the aerosols generated from the e-cigarettes. Protonation of the pyrrolidine nitrogen of nicotine molecules by addition of excess hydrochloric acid affords an aminium salt that is readily quantified by Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS). The kinetics of nicotine protonation was studied using ¹H NMR spectroscopy. Quantitative analyses of nicotine in commercial e-liquids and in the corresponding der

SUBMITTER: Ogunwale MA 

PROVIDER: S-EPMC5703602 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature