Selector genes display tumor cooperation and inhibition in Drosophila epithelium in a developmental context-dependent manner.

ABSTRACT: During animal development, selector genes determine identities of body segments and those of individual organs. Selector genes are also misexpressed in cancers, although their contributions to tumor progression per se remain poorly understood. Using a model of cooperative tumorigenesis, we show that gain of selector genes results in tumor cooperation, but in only select developmental domains of the wing, haltere and eye-antennal imaginal discs of Drosophila larva. Thus, the field selector, Eyeless (Ey), and the segment selector, Ultrabithorax (Ubx), readily cooperate to bring about neoplastic transformation of cells displaying somatic loss of the tumor suppressor, Lgl, but in only those developmental domains that express the homeo-box protein, Homothorax (Hth), and/or the Zinc-finge

SUBMITTER: Gupta RP 

PROVIDER: S-EPMC5703612 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature