Calenduloside E Analogues Protecting H9c2 Cardiomyocytes Against H₂O₂-Induced Apoptosis: Design, Synthesis and Biological Evaluation.

ABSTRACT: Modulation of apoptosis is therapeutically effective in cardiomyocytes damage. Calenduloside E (CE), a naturally occurring triterpenoid saponin, is a potent anti-apoptotic agent. However, little is known about its synthetic analogues on the protective effects in apoptosis of cardiomyocytes. The present research was performed to investigate the potential protective effect of CE analogues against H₂O₂-induced apoptosis in H9c2 cardiomyocytes and the underlying mechanisms. Sixteen novel CE anologues have been designed, synthesized and biological evaluation. Among the 16 CE anologues, as well as the positive control CE tested, compound 5d was the most effective in improving cardiomyocytes viability. Pretreatment with anologue 5d inhibited ROS generation, mai

SUBMITTER: Tian Y 

PROVIDER: S-EPMC5703861 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature