The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress.

ABSTRACT: Age-associated changes in chromatin structure have a major impact on organismal longevity. Despite being a central part of the ageing process, the organismal responses to the changes in chromatin organization remain unclear. Here we show that moderate disturbance of histone balance during C. elegans development alters histone levels and triggers a stress response associated with increased expression of cytosolic small heat-shock proteins. This stress response is dependent on the transcription factor, HSF-1, and the chromatin remodeling factor, ISW-1. In addition, we show that mitochondrial stress during developmental stages also modulates histone levels, thereby activating a cytosolic stress response similar to that caused by changes in histone balance. These data indicate that histone and

SUBMITTER: Matilainen O 

PROVIDER: S-EPMC5703887 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature