Young onset type 2 diabetic patients might be more sensitive to metformin compared to late onset type 2 diabetic patients.

ABSTRACT: It is unknown whether YOD (young onset diabetes) and LOD (late onset diabetes) require similar insulin doses for intensive insulin therapy with a metformin add-on to achieve glycemic control. We analyzed data from our two previously performed randomized, controlled open-label trials. Patients were randomized to receive either continuous subcutaneous insulin infusion (CSII) therapy or CSII combined with metformin therapy for 4 weeks. The studies concentrated on the differences in the insulin doses used for the two groups. We included 36 YOD (age < 40 yrs) and 152 LOD (age > 40 yrs) patients. YOD patients who received metformin combined with CSII therapy required significantly lower insulin doses to maintain euglycemic control compared to patients with LOD. A multivariate analysis, controlle

SUBMITTER: Li FF 

PROVIDER: S-EPMC5703958 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature