Impact of Oxidant Gases on the Relationship between Outdoor Fine Particulate Air Pollution and Nonaccidental, Cardiovascular, and Respiratory Mortality.

ABSTRACT: Outdoor fine particulate air pollution (PM_2.5) is known to increase mortality risk and is recognized as an important contributor to global disease burden. However, less is known about how oxidant gases may modify the chronic health effects of PM_2.5. In this study, we examined how the oxidant capacity of O₃ and NO₂ (using a redox-weighted average, O_x) may modify the relationship between PM_2.5 and mortality in the 2001 Canadian Census Health and Environment Cohort. In total, 2,448,500 people were followed over a 10.6-year period. Each 3.86 µg/m³ increase in PM_2.5 was associated with nonaccidental (Hazard Ratio (HR) = 1.095, 95% CI: 1.077, 1.112), cardiovascular (HR = 1.088, 95% CI: 1.059, 1.118), and resp

SUBMITTER: Weichenthal S 

PROVIDER: S-EPMC5703979 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature