Maternal gestational weight gain and DNA methylation in young women: application of life course mediation methods.

ABSTRACT:

Aim

To investigate the role of maternal gestational weight gain (GWG) and prepregnancy BMI on programming offspring DNA methylation.

Methods

Among 589 adult (age = 32) women participants of the Jerusalem Perinatal Study, we quantified DNA methylation in five candidate genes. We used inverse probability-weighting and parametric g-formula to estimate direct effects of maternal prepregnancy BMI and GWG on methylation.

Results

Higher maternal GWG, but not prepregnancy BMI, was inversely related to offspring ABCA1 methylation (β = -1.1% per quartile; 95% CI: -2.0, -0.3) after accounting for ancestry, parental and offspring exposures. Total and controlled direct effects were nearly identical suggesting included offspring exposures did not mediate this relationship. Results

SUBMITTER: Huang JY 

PROVIDER: S-EPMC5704089 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature