MiRNA processing gene polymorphisms, blood DNA methylation age and long-term ambient PM_2.5 exposure in elderly men.

ABSTRACT:

Aim

We tested whether genetic variation in miRNA processing genes modified the association of PM_2.5 with DNA methylation (DNAm) age.

Patients & methods

We conducted a repeated measures study based on 552 participants from the Normative Aging Study with multiple visits between 2000 and 2011 (n = 940 visits). Address-level 1-year PM_2.5 exposures were estimated using the GEOS-chem model. DNAm-age and a panel of 14 SNPs in miRNA processing genes were measured from participant blood samples.

Results & conclusion

In fully adjusted linear mixed-effects models, having at least one copy of the minor rs4961280 [AGO2] allele was associated with a lower DNAm-age (β = -1.13; 95% CI: -2.26 to -0.002). However, the association of PM_2.5 with DNAm-age

SUBMITTER: Nwanaji-Enwerem JC 

PROVIDER: S-EPMC5704092 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature