The Pattern of microRNA Binding Site Distribution.

ABSTRACT: Micro-RNA (miRNA or miR) regulates at least 60% of the genes in the human genome through their target sites at mRNA 3'-untranslated regions (UTR), and defects in miRNA expression regulation and target sites are frequently observed in cancers. We report here a systematic analysis of the distribution of miRNA target sites. Using the evolutionarily conserved miRNA binding sites in the TargetScan database (release 7.1), we constructed a miRNA co-regulation network by connecting genes sharing common miRNA target sites. The network possesses characteristics of the ubiquitous small-world network. Non-hub genes in the network-those sharing miRNA target sites with small numbers of genes-tend to form small cliques with their neighboring genes, while hub genes exhibit high levels of promiscuousness i

SUBMITTER: Zhang F 

PROVIDER: S-EPMC5704209 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature