Value of soluble Urokinase plasminogen activator receptor over age as a biomarker of impaired myocardial relaxation.

ABSTRACT: BACKGROUND:SuPAR is a biomarker that reflects the level of immune activation. As inflammation plays an important role in the ageing process of the cardiovascular system, we hypothesized that suPAR might be a useful predictive biomarker of the ageing heart. METHODS:We performed conventional and tissue Doppler echocardiography and measured plasma suPAR levels. RESULTS:We studied community adults (n=120, 37.5% female) (mean age: 70.3±9.3 years) without known cardiovascular disease (CVD). Participants with impaired myocardial relaxation were older (84% vs 59% were aged ≥71 years, p=0.002), with more diabetes mellitus (27% vs 11%, p=0.034). SuPAR levels were higher among participants with impaired myocardial relaxation (3.9 ng/ml vs 3.0 ng/ml, p=0.015). At the univariate level, older age (OR 3.

SUBMITTER: Koh AS 

PROVIDER: S-EPMC5704352 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature