Drug repurposing for the treatment of glioblastoma multiforme.

ABSTRACT:

Background

Glioblastoma Multiforme is the deadliest type of brain tumor and is characterized by very poor prognosis with a limited overall survival. Current optimal therapeutic approach has essentially remained unchanged for more than a decade, consisting in maximal surgical resection followed by radiotherapy plus temozolomide.

Main body

Such a dismal patient outcome represents a compelling need for innovative and effective therapeutic approaches. Given the development of new drugs is a process presently characterized by an immense increase in costs and development time, drug repositioning, finding new uses for existing approved drugs or drug repurposing, re-use of old drugs when novel molecular findings make them attractive again, are gaining significance in clinical pharma

SUBMITTER: Abbruzzese C 

PROVIDER: S-EPMC5704391 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature