Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage.

ABSTRACT:

Background

Human amniotic epithelial cells (hAECs) are attractive candidates for regenerative medical therapy, with the potential to replace deficient cells and improve functional recovery after injury. Previous studies have demonstrated that transplantation of hAECs effectively alleviate chemotherapy-induced ovarian damage via inhibiting granulose cells apoptosis in animal models of premature ovarian failure/insufficiency (POF/POI). However, the underlying molecular mechanism accounting for hAECs-mediated ovarian function recovery is not fully understood.

Methods

To investigate whether hAECs-secreting cytokines act as molecular basis to attenuate chemotherapy-induced ovarian injury, hAECs or hAEC-conditioned medium (hAEC-CM) was injected into the unilateral ovary of POF/POI

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC5704397 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature