Neuroimaging genomics in psychiatry-a translational approach.

ABSTRACT: Neuroimaging genomics is a relatively new field focused on integrating genomic and imaging data in order to investigate the mechanisms underlying brain phenotypes and neuropsychiatric disorders. While early work in neuroimaging genomics focused on mapping the associations of candidate gene variants with neuroimaging measures in small cohorts, the lack of reproducible results inspired better-powered and unbiased large-scale approaches. Notably, genome-wide association studies (GWAS) of brain imaging in thousands of individuals around the world have led to a range of promising findings. Extensions of such approaches are now addressing epigenetics, gene-gene epistasis, and gene-environment interactions, not only in brain structure, but also in brain function. Complementary developments in sys

SUBMITTER: Mufford MS 

PROVIDER: S-EPMC5704437 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature