Association of Interleukin-1 gene clusters polymorphisms with primary open-angle glaucoma: a meta-analysis.

ABSTRACT:

Background

Previous studies have associated the Interleukin-1 (IL-1) gene clusters polymorphisms with the risk of primary open-angle glaucoma (POAG). However, the results were not consistent. Here, we performed a meta-analysis to evaluate the role of IL-1 gene clusters polymorphisms in POAG susceptibility.

Methods

PubMed, EMBASE and Cochrane Library (up to July 15, 2017) were searched by two independent investigators. All case-control studies investigating the association between single-nucleotide polymorphisms (SNPs) of IL-1 gene clusters and POAG risk were included. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for quantifying the strength of association that has been involved in at least two studies.

Results

Five studies on IL-1β rs16944 (c.

SUBMITTER: Li J 

PROVIDER: S-EPMC5704439 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature