Low flow extracorporeal CO₂ removal in ARDS patients: a prospective short-term crossover pilot study.

ABSTRACT:

Background

Lung protective mechanical ventilation (MV) is the corner stone of therapy for ARDS. However, its use may be limited by respiratory acidosis. This study explored feasibility of, effectiveness and safety of low flow extracorporeal CO₂ removal (ECCO₂R).

Methods

This was a prospective pilot study, using the Abylcap® (Bellco) ECCO₂R, with crossover off-on-off design (2-h blocks) under stable MV settings, and follow up till end of ECCO₂R. Primary endpoint for effectiveness was a 20% reduction of PaCO₂ after the first 2-h. Adverse events (AE) were recorded prospectively. We included 10 ARDS patients on MV, with PaO₂/FiO₂ < 150 mmHg, tidal volume ≤ 8 mL/kg with positive end-expiratory pressure ≥

SUBMITTER: Peperstraete H 

PROVIDER: S-EPMC5704518 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature