RDL mutations predict multiple insecticide resistance in Anopheles sinensis in Guangxi, China.

ABSTRACT:

Background

Anopheles sinensis is a major vector of malaria in China. The gamma-aminobutyric acid (GABA)-gated chloride channel, encoded by the RDL (Resistant to dieldrin) gene, is the important target for insecticides of widely varied structures. The use of various insecticides in agriculture and vector control has inevitably led to the development of insecticide resistance, which may reduce the control effectiveness. Therefore, it is important to investigate the presence and distribution frequency of the resistance related mutation(s) in An. sinensis RDL to predict resistance to both the withdrawn cyclodienes (e.g. dieldrin) and currently used insecticides, such as fipronil.

Methods

Two hundred and forty adults of An. sinensis collected from nine locations across Guangxi Zh

SUBMITTER: Yang C 

PROVIDER: S-EPMC5704519 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature