High resolution chromosomal microarray analysis in paediatric obsessive-compulsive disorder.

ABSTRACT:

Background

Obsessive-Compulsive Disorder (OCD) is a common and chronic disorder in which a person has uncontrollable, reoccurring thoughts and behaviours. It is a complex genetic condition and, in case of early onset (EO), the patients manifest a more severe phenotype, and an increased heritability. Large (>500 kb) copy number variations (CNVs) previously associated with autism and schizophrenia have been reported in OCD. Recently, rare CNVs smaller than 500 kb overlapping risk loci for other neurodevelopmental conditions have also been reported in OCD, stressing the importance of examining CNVs of any size range. The aim of this study was to further investigate the role of rare and small CNVs in the aetiology of EO-OCD.

Methods

We performed high-resolution chromosomal micro

SUBMITTER: Grunblatt E 

PROVIDER: S-EPMC5704537 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature