Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians.

ABSTRACT:

Background

Genome-wide single marker and gene-based meta-analyses of long-term average (LTA) blood pressure (BP) phenotypes may reveal novel findings for BP.

Methods and results

We conducted genome-wide analysis among 18 422 East Asian participants (stage 1) followed by replication study of ≤46 629 participants of European ancestry (stage 2). Significant single-nucleotide polymorphisms and genes were determined by a P<5.0×10^-8 and 2.5×10^-6, respectively, in joint analyses of stage-1 and stage-2 data. We identified 1 novel ARL3 variant, rs4919669 at 10q24.32, influencing LTA systolic BP (stage-1 P=5.03×10^-8, stage-2 P=8.64×10^-3, joint P=2.63×10^-8

SUBMITTER: Li C 

PROVIDER: S-EPMC5704911 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature