α-Actinin Promotes Surface Localization and Current Density of the Ca²⁺ Channel Ca_V1.2 by Binding to the IQ Region of the α1 Subunit.

ABSTRACT: The voltage-gated L-type Ca²⁺ channel Ca_V1.2 is crucial for initiating heartbeat and control of a number of neuronal functions such as neuronal excitability and long-term potentiation. Mutations of Ca_V1.2 subunits result in serious health problems, including arrhythmia, autism spectrum disorders, immunodeficiency, and hypoglycemia. Thus, precise control of Ca_V1.2 surface expression and localization is essential. We previously reported that α-actinin associates and colocalizes with neuronal Ca_V1.2 channels and that shRNA-mediated depletion of α-actinin significantly reduces localization of endogenous Ca_V1.2 in dendritic spines in hippocampal neurons. Here we investigated the hypothesis that direct binding of α-actinin to Ca

SUBMITTER: Tseng PY 

PROVIDER: S-EPMC5704914 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature