Switching the Immunogenicity of Peptide Assemblies Using Surface Properties.

ABSTRACT: Biomaterials created from supramolecular peptides, proteins, and their derivatives have been receiving increasing interest for both immunological applications, such as vaccines and immunotherapies, as well as ostensibly nonimmunological applications, such as therapeutic delivery or tissue engineering. However, simple rules for either maximizing immunogenicity or abolishing it have yet to be elucidated, even though immunogenicity is a prime consideration for the design of any supramolecular biomaterial intended for use in vivo. Here, we investigated a range of physicochemical properties of fibrillized peptide biomaterials, identifying negative surface charge as a means for completely abolishing antibody and T cell responses against them in mice, even when they display a competent epitope. T

SUBMITTER: Wen Y 

PROVIDER: S-EPMC5704984 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature