A Missense Variant in PLEC Increases Risk of Atrial Fibrillation.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have yielded variants at >30 loci that associate with atrial fibrillation (AF), including rare coding mutations in the sarcomere genes MYH6 and MYL4.

Objectives

The aim of this study was to search for novel AF associations and in doing so gain insights into the mechanisms whereby variants affect AF risk, using electrocardiogram (ECG) measurements.

Methods

The authors performed a GWAS of 14,255 AF cases and 374,939 controls, using whole-genome sequence data from the Icelandic population, and tested novel signals in 2,002 non-Icelandic cases and 12,324 controls. They then tested the AF variants for effect on cardiac electrical function by using measurements in 289,297 ECGs from 62,974 individuals.

Results

The auth

SUBMITTER: Thorolfsdottir RB 

PROVIDER: S-EPMC5704994 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature