A small molecule--DNA binding landscape.

ABSTRACT: This brief account traces the development of a "competition dialysis" method used to characterize the structural and sequence selectivity of DNA binding compounds. The method was inspired by a simple "differential dialysis" method pioneered by Don Crothers to explore base-selective intercalator binding. Results from compiled competition dialysis studies provide a small-molecule DNA binding landscape that shows a rich diversity of interactions and molecular recognition.

SUBMITTER: Chaires JB 

PROVIDER: S-EPMC5705039 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature