Shedding New Light on the Process of "Licensing" for Pathogenicity by Th Lymphocytes.

ABSTRACT: Th cells sensitized against autoantigens acquire pathogenicity following two sequential events, namely activation by their target Ag and a process named "licensing." In this study, we analyzed these processes in a transgenic mouse system in which TCR-transgenic Th cells specific to hen egg lysozyme (HEL) are adoptively transferred to recipients and induce inflammation in eyes expressing HEL. Our data show that the notion that the lung is the organ where "licensing" for pathogenicity takes place is based on biased data collected with cells injected i.v., a route in which most transferred cells enter via the lung. Thus, we found that when donor cells were activated in vitro and injected intraperitoneally, or were activated in vivo, they migrated simultaneously to the lung, spleen, and other

SUBMITTER: Tan C 

PROVIDER: S-EPMC5705095 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature