Katanin-like 2 (KATNAL2) functions in multiple aspects of haploid male germ cell development in the mouse.

ABSTRACT: The katanin microtubule-severing proteins are essential regulators of microtubule dynamics in a diverse range of species. Here we have defined critical roles for the poorly characterised katanin protein KATNAL2 in multiple aspects of spermatogenesis: the initiation of sperm tail growth from the basal body, sperm head shaping via the manchette, acrosome attachment, and ultimately sperm release. We present data suggesting that depending on context, KATNAL2 can partner with the regulatory protein KATNB1 or act autonomously. Moreover, our data indicate KATNAL2 may regulate δ- and ε-tubulin rather than classical α-β-tubulin microtubule polymers, suggesting the katanin family has a greater diversity of function than previously realised. Together with our previous research, showing the essential

SUBMITTER: Dunleavy JEM 

PROVIDER: S-EPMC5705150 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature