Evolution of host adaptation in the Salmonella typhoid toxin.

ABSTRACT: The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host ^1-5 . Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen Salmonella Typhi ^6,7 , the cause of typhoid fever in humans ^8-12 . Typhoid toxin has a unique A₂B₅ architecture with two covalently linked enzymatic 'A' subunits, PltA and CdtB, associated with a homopentameric 'B' subunit made up of PltB, which has binding specificity for the N-acetylneuraminic acid (Neu5Ac) sialoglycans ^6,13 prominently present in humans ¹⁴ . Here, we examine the functional and structural relationship between typhoid toxin and ArtAB, an evolutionarily related A

SUBMITTER: Gao X 

PROVIDER: S-EPMC5705260 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature