The major targets of acute norovirus infection are immune cells in the gut-associated lymphoid tissue.

ABSTRACT: Noroviruses are the leading cause of food-borne gastroenteritis outbreaks and childhood diarrhoea globally, estimated to be responsible for 200,000 deaths in children each year ^1-4 . Thus, reducing norovirus-associated disease is a critical priority. Development of vaccines and therapeutics has been hindered by the limited understanding of basic norovirus pathogenesis and cell tropism. While macrophages, dendritic cells, B cells and stem-cell-derived enteroids can all support infection of certain noroviruses in vitro ^5-7 , efforts to define in vivo norovirus cell tropism have generated conflicting results. Some studies detected infected intestinal immune cells ^8-12 , other studies detected epithelial cells ¹³ , and still others detected immune an

SUBMITTER: Grau KR 

PROVIDER: S-EPMC5705318 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature