BDNF Val⁶⁶Met polymorphism tunes frontolimbic circuitry during affective contextual learning.

ABSTRACT: Adaptive learning impairments are common in cognitive and behavioral disorders, but the neurogenetic mechanisms supporting human affective learning are poorly understood. We designed a higher-order contextual learning task in which healthy participants genotyped for the Val⁶⁶Met polymorphism of the brain derived neurotropic factor gene (BDNF) were required to choose the member of a picture pair most congruent with the emotion in a previously-viewed facial expression video in order to produce an advantageous monetary outcome. Functional magnetic resonance imaging (fMRI) identified frontolimbic blood oxygenation level dependent (BOLD) reactivity that was associated with BDNF Val⁶⁶Met genotype during all three phases of the learning task: aversive and reward-predictive l

SUBMITTER: Jabbi M 

PROVIDER: S-EPMC5705347 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature