Kidney function, bone-mineral metabolism markers, and future risk of peripheral artery disease.

ABSTRACT:

Background and aims

Reduced kidney function is a risk factor for lower-extremity peripheral artery disease (PAD). However, the associations of novel filtration markers with PAD are yet to be quantified. Moreover, little is known on whether bone-mineral metabolism (BMM) markers are related to incident PAD beyond kidney function.

Methods

Using data from 12,472 participants at baseline (1990-1992) of the Atherosclerosis Risk in Communities (ARIC) study, we comprehensively quantified the associations of kidney related markers with incident PAD (defined as hospitalizations with diagnosis of lower-extremity atherosclerosis, revascularization, or amputation). Kidney related markers of interest included estimated glomerular filtration rate (eGFR) (based on creatinine, cystatin C, an

SUBMITTER: Yang C 

PROVIDER: S-EPMC5705382 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature