Sustained Molecular Pathology Across Episodes and Remission in Major Depressive Disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) is a debilitating mental illness and a major cause of lost productivity worldwide. MDD patients often suffer from lifelong recurring episodes of increasing severity, reduced therapeutic response, and shorter remission periods, suggesting the presence of a persistent and potentially progressive pathology.

Methods

Subgenual anterior cingulate cortex postmortem samples from four MDD cohorts (single episode, n = 20; single episode in remission, n = 15; recurrent episode, n = 20; and recurrent episode in remission, n = 15), and one control cohort (n = 20) were analyzed by mass spectrometry-based proteomics (n = 3630 proteins) combined with statistical analyses. The data was investigated for trait and state progressive neuropathologies in

SUBMITTER: Scifo E 

PROVIDER: S-EPMC5705452 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature