Small molecules to the rescue: Inhibition of cytokine signaling in immune-mediated diseases.

ABSTRACT: Cytokines are small, secreted proteins associated with the maintenance of immune homeostasis but also implicated with the pathogenesis of several autoimmune and inflammatory diseases. Biologic agents blocking cytokines or their receptors have revolutionized the treatment of such pathologies. Nonetheless, some patients fail to respond to these drugs or do not achieve complete remission. The signal transduction originating from membrane-bound cytokine receptors is an intricate network of events that lead to gene expression and ultimately regulate cellular functionality. Our understanding of the intracellular actions that molecules such as interleukins, interferons (IFNs) and tumor necrosis factor (TNF) set into motion has greatly increased in the past few years, making it possible to interfe

SUBMITTER: Gadina M 

PROVIDER: S-EPMC5705536 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature