Interventions for management of post-stroke depression: A Bayesian network meta-analysis of 23 randomized controlled trials.

ABSTRACT: Post-stroke depression (PSD) is an important complication of stroke, leading to increased disability and mortality. Given that there is no consensus on which treatment is optimal for PSD, we aimed to evaluate the relative efficacies of available pharmacological and non-pharmacological interventions. We conducted a network meta-analysis to incorporate evidence from relevant trials and provide direct and indirect comparisons. We searched PubMed, Cochrane Library Central Register of Controlled Trials, and Embase until November 1, 2016 for randomized controlled trials involving different pharmacological and non-pharmacological PSD treatment interventions. The primary outcome was reduction in the Hamilton depression scale (HAMD) score. This study is registered with PROSPERO (number, CRD42016049

SUBMITTER: Deng L 

PROVIDER: S-EPMC5705605 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature