Differential effects on membrane permeability and viability of human keratinocyte cells undergoing very low intensity megasonic fields.

ABSTRACT: Among different therapeutic applications of Ultrasound (US), transient membrane sonoporation (SP) - a temporary, non-lethal porosity, mechanically induced in cell membranes through US exposure - represents a compelling opportunity towards an efficient and safe drug delivery. Nevertheless, progresses in this field have been limited by an insufficient understanding of the potential cytotoxic effects of US related to the failure of the cellular repair and to the possible activation of inflammatory pathway. In this framework we studied the in vitro effects of very low-intensity US on a human keratinocyte cell line, which represents an ideal model system of skin protective barrier cells which are the first to be involved during medical US treatments. Bioeffects linked to US application at 1 MHz

SUBMITTER: Domenici F 

PROVIDER: S-EPMC5705699 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature