Soluble intercellular adhesion molecule-1: a potential biomarker for pain intensity in chronic pain patients.

ABSTRACT:

Aim

Pain therapy is strongly guided by patients' self-reporting. However, when self-reporting is not an option, pain assessment becomes a challenge and may lead to undertreatment of painful conditions. Pain is a complex and multifactorial phenomenon. Recent work has connected pain pathophysiology also with the inflammatory system. We therefore hypothesized that pain intensity could be predicted by cytokine-levels.

Patients & methods

In this observational, single-center study, we investigated 30 serum cytokines to predict pain intensity in a screening/follow-up set of 95 chronic pain patients and controls. We then prospectively validated soluble intercellular adhesion molecule-1 (sICAM-1)'s discriminatory capability (n = 21).

Results & conclusion

sICAM-1 was significan

SUBMITTER: Luchting B 

PROVIDER: S-EPMC5705790 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature