The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells.
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ABSTRACT:
SUBMITTER: Wilson D
PROVIDER: S-EPMC5705961 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells.
Wilson David D Boyle Glen M GM McIntyre Lachlan L Nolan Matthew J MJ Parsons Peter G PG Smith Jennifer J JJ Tribolet Leon L Loukas Alex A Liddell Michael J MJ Rash Lachlan D LD Daly Norelle L NL
Toxins 20171027 11
Spider venoms constitute incredibly diverse libraries of compounds, many of which are involved in prey capture and defence. Polyamines are often prevalent in the venom and target ionotropic glutamate receptors. Here we show that a novel spider polyamine, PA<sub>366</sub>, containing a hydroxyphenyl-based structure is present in the venom of several species of tarantula, and has selective toxicity against MCF-7 breast cancer cells. By contrast, a polyamine from an Australian funnel-web spider ven ...[more]
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