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Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59.


ABSTRACT: Anandins A (1) and B (2), two rare steroidal alkaloids, were isolated from the fermentative broth of a marine actinobacteria Streptomyces anandii H41-59. The gross structures of the two alkaloids were elucidated by spectroscopic methods including HR-ESI-MS, and NMR. Their absolute configurations were confirmed by single-crystal X-ray diffraction analysis and comparison of their experimental and calculated electronic circular dichroism spectra, respectively. Anandin A exhibited a moderate inhibitory effect against three human cancer cell lines MCF-7, SF-268, and NCI-H460 with IC50 values of 7.5, 7.9, 7.8 ?g/mL, respectively.

SUBMITTER: Zhang YM 

PROVIDER: S-EPMC5706044 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59.

Zhang Yang-Mei YM   Liu Bai-Lian BL   Zheng Xin-Heng XH   Huang Xiao-Jun XJ   Li Hong-Yu HY   Zhang Ying Y   Zhang Ting-Ting TT   Sun Da-Yuan DY   Lin Bi-Run BR   Zhou Guang-Xiong GX  

Marine drugs 20171110 11


Anandins A (<b>1</b>) and B (<b>2</b>), two rare steroidal alkaloids, were isolated from the fermentative broth of a marine actinobacteria <i>Streptomyces anandii</i> H41-59. The gross structures of the two alkaloids were elucidated by spectroscopic methods including HR-ESI-MS, and NMR. Their absolute configurations were confirmed by single-crystal X-ray diffraction analysis and comparison of their experimental and calculated electronic circular dichroism spectra, respectively. Anandin A exhibit  ...[more]

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