Optimizing fresh specimen staining for rapid identification of tumor biomarkers during surgery.

ABSTRACT:

Rationale

Positive margin status due to incomplete removal of tumor tissue during breast conserving surgery (BCS) is a prevalent diagnosis usually requiring a second surgical procedure. These follow-up procedures increase the risk of morbidity and delay the use of adjuvant therapy; thus, significant efforts are underway to develop new intraoperative strategies for margin assessment to eliminate re-excision procedures. One strategy under development uses topical application of dual probe staining and a fluorescence imaging strategy termed dual probe difference specimen imaging (DDSI). DDSI uses a receptor-targeted fluorescent probe and an untargeted, spectrally-distinct fluorescent companion imaging agent topically applied to fresh resected specimens, where the fluorescence from eac

SUBMITTER: Barth CW 

PROVIDER: S-EPMC5706095 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature