Minor physical anomalies in neurodevelopmental disorders: a twin study.

ABSTRACT:

Background

Minor physical anomalies (MPAs) are subtle anatomical deviations in one's appearance and may suggest altered embryogenesis. MPAs have been shown to be more common in neurodevelopmental disorders (NDDs) compared with typical development. Still, further studies are needed on MPAs in NDDs, especially using twins to adjust for confounding familial factors.

Methods

Clinical assessments were conducted on 116 twins (61 NDD, 55 controls) from 51 monozygotic and 7 dizygotic pairs to examine MPAs and their association with DSM-5 defined NDDs. Additionally, the relationship between the number of MPAs within twins by zygosity was investigated.

Results

Within the cohort sample, a specific association was found between MPAs and autism spectrum disorder (ASD) diagnosis (c

SUBMITTER: Myers L 

PROVIDER: S-EPMC5706157 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature