WWC2 is an independent prognostic factor and prevents invasion via Hippo signalling in hepatocellular carcinoma.

ABSTRACT: WWC family proteins negatively regulate HEK293 cell proliferation and organ growth by suppressing the transcriptional activity of Yes-associated protein (YAP), a major effector of the Hippo pathway. The function of the scaffolding protein WWC1 (also called KIBRA) has been intensively studied in cells and animal models. However, the expression and clinicopathologic significance of WWC2 in cancer are poorly characterized. This study aimed to clarify the biological function and mechanism of action of WWC2 in hepatocellular carcinoma (HCC). Retrospective analysis revealed WWC2 was significantly down-regulated in 95 clinical HCC tissues compared to the paired adjacent non-cancerous tissues. Moreover, loss of WWC2 expression was significantly associated with advanced clinicopathological features

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5706493 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature