Effects of white light-emitting diode (LED) exposure on retinal pigment epithelium in vivo.

ABSTRACT: Ageing and alteration of the functions of the retinal pigment epithelium (RPE) are at the origin of lost of vision seen in age-related macular degeneration (AMD). The RPE is known to be vulnerable to high-energy blue light. The white light-emitting diodes (LED) commercially available have relatively high content of blue light, a feature that suggest that they could be deleterious for this retinal cell layer. The aim of our study was to investigate the effects of "white LED" exposure on RPE. For this, commercially available white LEDs were used for exposure experiments on Wistar rats. Immunohistochemical stain on RPE flat mount, transmission electron microscopy and Western blot were used to exam the RPE. LED-induced RPE damage was evaluated by studying oxidative stress, stress response path

SUBMITTER: Jaadane I 

PROVIDER: S-EPMC5706508 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature