Catalase ameliorates diabetes-induced cardiac injury through reduced p65/RelA- mediated transcription of BECN1.

ABSTRACT: Catalase is an antioxidative enzyme that converts hydrogen peroxide (H₂ O₂ ) produced by superoxide dismutase from highly reactive superoxide (O₂^- ) to water and oxygen molecules. Although recent findings demonstrate that catalase, autophagy and the nuclear factor κB (NF-κB) signalling pathway are centrally involved in diabetic cardiomyopathy (DCM), the interplay between the three has not been fully characterized. Thus, the mechanism responsible for catalase-mediated protection against heart injury in diabetic mice was investigated in this study, as well as the role of NF-κB-p65 in the regulation of autophagic flux was investigated in this study. Western blot analysis revealed that catalase inhibited NF-κB activity and decreased LC3-II (microtubu

SUBMITTER: Wang X 

PROVIDER: S-EPMC5706580 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature