Leukotriene B₄-receptor-1 mediated host response shapes gut microbiota and controls colon tumor progression.

ABSTRACT: Inflammation and infection are key promoters of colon cancer but the molecular interplay between these events is largely unknown. Mice deficient in leukotriene B₄ receptor1 (BLT1) are protected in inflammatory disease models of arthritis, asthma and atherosclerosis. In this study, we show that BLT1^-/- mice when bred onto a spontaneous tumor (Apc^Min/+) model displayed an increase in the rate of intestinal tumor development and mortality. A paradoxical increase in inflammation in the tumors from the BLT1^-/-Apc^Min/+ mice is coincidental with defective host response to infection. Germ-free BLT1^-/-Apc^Min/+ mice are free from colon tumors that reappeared upon fecal transplanta

SUBMITTER: Jala VR 

PROVIDER: S-EPMC5706601 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature