The adaptive immune system promotes initiation of prostate carcinogenesis in a human c-Myc transgenic mouse model.

ABSTRACT: Increasing evidence from epidemiological and pathological studies suggests a role of the immune system in the initiation and progression of multiple cancers, including prostate cancer. Reports on the contribution of the adaptive immune system are contradictive, since both suppression and acceleration of disease development have been reported. This study addresses the functional role of lymphocytes in prostate cancer development using a genetically engineered mouse model (GEMM) of human c-Myc driven prostate cancer (Hi-Myc mice) combined with B and T cell deficiency (RAG1^-/- mice). From a pre-cancerous stage on, Hi-Myc mice showed higher accumulation of immune cells in their prostates then wild-type mice, of which macrophages were the most abundant. The onset of invasive adenocar

SUBMITTER: Melis MHM 

PROVIDER: S-EPMC5706841 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature