Targeted inhibition of glutaminase as a potential new approach for the treatment of NF1 associated soft tissue malignancies.

ABSTRACT: Many cancer cells rely on glutamine as the source of carbon molecules to feed the biosynthetic pathways and are often addicted to glutaminolysis. Inhibitors of glutaminase activity have gained attention in the last few years due to their anti-proliferative effect and ability to induce apoptosis in some cancers. Although it is a promising therapeutic approach, its efficacy or the role played by glutamine in modulating cell proliferation in NF1 associated tumors has never been studied. We report for the first time, a strong correlation between the NF1 status of tumor cells and increased sensitivity to glutamine deprivation and glutaminase inhibition. Soft-tissue cell lines null for NF1 were highly dependent on glutamine for proliferation and showed decreased mTORC1 and R

SUBMITTER: Sheikh TN 

PROVIDER: S-EPMC5706855 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature