Low circulating levels of the mitochondrial-peptide hormone SHLP2: novel biomarker for prostate cancer risk.

ABSTRACT:

Context

Mitochondrial DNA mutations and dysfunction are associated with prostate cancer (PCa). Small humanin-like peptide-2 (SHLP2) is a novel mitochondrial-encoded peptide and an important mitochondrial retrograde signaling molecule.

Objective

To determine whether serum SHLP2 concentration is associated with PCa risk and whether associations are race-specific.Design, Setting and Participants: Patients undergoing prostate biopsy were recruited from the Durham Veterans Affairs hospital. Serum was collected prior to biopsy and SHLP2 measured by ELISA. We selected 200 men for analysis (100 negative biopsies and 100 PCa cases; 100 black and 100 white).

Results

Mean SHLP2 levels were significantly higher in white controls versus black controls and SHLP2 was significantly h

SUBMITTER: Xiao J 

PROVIDER: S-EPMC5706922 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature