High PTPN13 expression in high grade serous ovarian carcinoma is associated with a better patient outcome.

ABSTRACT:

Background

Chromosome 4q loss of heterozygosity (LOH) is frequently observed in high-grade serous ovarian carcinoma (HGSOC). However, this LOH has not been clearly associated with the inactivation of any tumor suppressor gene(s). As the tumor suppressor gene PTPN13 is located on chromosome 4q21, we investigated its expression in HGSOC.

Methods

PTPN13 protein expression was investigated by immunohistochemistry (IHC) in normal ovary epithelium and in 30 HGSOC samples, whereas PTPN13 mRNA expression was quantified by RT-PCR in another independent cohort of 28 HGSOC samples. Patients in both cohorts were followed for more than 8.5 years.

Results

PTPN13 protein expression was lower in one third of HGSOC samples compared with normal ovary epithelium. In both c

SUBMITTER: D'Hondt V 

PROVIDER: S-EPMC5707051 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature