Inflammatory biomarkers in metastatic colorectal cancer: prognostic and predictive role beyond the first line setting.

ABSTRACT:

Introduction

Inflammatory biomarkers are useful prognostic tools in cancer patients. However, the prognostic and predictive value of inflammatory biomarkers beyond the 1^st-line setting in metastatic colorectal cancer (mCRC) is unclear.

Results

In multivariate analysis 1 standard deviation increase in neutrophil-lymphocyte-ratio (NLR) was associated with an 8.5% absolute lower objective-response-rate (ORR) in 1^st-line (p<0.0001), 3% lower ORR in 2^nd-line (p< 0.0001), and 3% lower ORR in 3^rd-line (p=0.24), respectively. Regarding progression free survival (PFS), an increase in the NLR was significantly associated with rising hazard-ratios (HR) over all treatment lines (HR=1.30, p= 0.021 1^st-line); (HR=1.37, p<0.0001 2

SUBMITTER: Riedl JM 

PROVIDER: S-EPMC5707080 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature