Altered microRNA profiles during early colon adenoma progression in a porcine model of familial adenomatous polyposis.

ABSTRACT: MicroRNAs are dysregulated in various cancers including colorectal cancer, and are potential useful biomarkers of disease development. We used next generation sequencing to investigate miRNA expression profiles in low- and high-grade intraepithelial dysplastic polyps from pigs carrying a mutation in the adenomatous polyposis coli tumour suppressor (APC¹³¹¹ , orthologous to human APC¹³⁰⁹ ) that model an inherited predisposition to colorectal cancer, familial adenomatous polyposis. We identified several miRNAs and their isomiRs significantly (P < 0.05) differentially expressed between low and high-grade intraepithelial dysplastic polyps. Of these, ssc-let-7e, ssc-miR-98, ssc-miR-146a-5p, ssc-miR-146b, ssc-miR-183 and ssc-miR-196a were expressed at h

SUBMITTER: Stachowiak M 

PROVIDER: S-EPMC5707088 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature