Prognostic value of MICA/B in cancers: a systematic review and meta-analysis.

ABSTRACT:

Purpose

MHC class I chain related-proteins A (MICA) and B (MICB) are natural killer group 2D ligands that mediate tumor surveillance. Several studies have suggested that MICA/B levels predict clinical outcomes in patients with cancer; however, this remains contentious. Here, we present a systematic review and meta-analysis of available studies of the prognostic value of MICA/B in cancer.

Materials and methods

We searched PubMed, Embase, Clinicaltrials.gov, and Cochrane Library to identify studies published from inception to July 2017 that assessed MICA/B in patients with cancer. The hazard ratio (HR) and 95% confidence interval (CI) of MICA/B were extracted for overall survival (OS) analysis.

Results

A total of 19 studies comprising 2,588 patients with 10 different ty

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC5707108 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature