Increased brain connectivity and activation after cognitive rehabilitation in Parkinson's disease: a randomized controlled trial.

ABSTRACT: Cognitive rehabilitation programs have demonstrated efficacy in improving cognitive functions in Parkinson's disease (PD), but little is known about cerebral changes associated with an integrative cognitive rehabilitation in PD. To assess structural and functional cerebral changes in PD patients, after attending a three-month integrative cognitive rehabilitation program (REHACOP). Forty-four PD patients were randomly divided into REHACOP group (cognitive rehabilitation) and a control group (occupational therapy). T1-weighted, diffusion weighted and functional magnetic resonance images (fMRI) during resting-state and during a memory paradigm (with learning and recognition tasks) were acquired at pre-treatment and post-treatment. Cerebral changes were assessed with repeated measures ANOVA 2 

SUBMITTER: Diez-Cirarda M 

PROVIDER: S-EPMC5707237 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature