A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer.

ABSTRACT: Prostaglandin E2 (PGE2) is associated with proliferation and angiogenesis in colorectal tumours. The role of prostaglandin transporter OATP2A1/SLCO2A1 in colon cancer tumorogenesis is unknown. We evaluated mice of various Slco2a1 genotypes in a murine model of colon cancer, the adenomatous polyposis (APC) mutant (Apc ∆716/+) model. Median lifespan was significantly extended from 19 weeks in Slco2a1 +/+/Apc Δ716/+ mice to 25 weeks in Slco2a1 -/-/Apc Δ716/+ mice. Survival was directly related to a reduction in the number of large polyps in the Slco2a1 -/- /Apc ∆716/+ compared to the Slco2a1 +/+/Apc Δ716/+ or Slco2a1 +/-/Apc Δ716/+mice. The large polyps from the Slco2a1 -/- /Apc ∆716/+ mice had significant reductions in microvascular density, consistent with the high expression of Slco2a1 in

SUBMITTER: Nakanishi T 

PROVIDER: S-EPMC5707394 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature